How Psoriasis Changes as Women Age

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The effects of psoriasis change throughout a woman’s lifespan. Many experts think
hormones trigger immune system changes in the skin of women with psoriasis, so symptoms may get worse or better at certain times in your life.

Here’s what you can expect.


Around ages 7-13, your body starts making sex hormones, such as estrogen and progesterone.

These hormones may play a role in
inflammation and affect the immune system, causing psoriasis to appear or flare (get worse).


The first time you get your period, high levels of estrogen can cause the overproduction of certain skin cells, which can make psoriasis worse.

Hormone levels go up and down during your menstrual cycle, so your psoriasis may flare or get better at different times of the month.

Many women say their psoriasis gets worse
right before their period, when estrogen levels are low. Symptoms might get better during the middle of your cycle, when estrogen levels are highest.


During pregnancy, your body produces high levels of estrogen and other hormones that may provide a temporary break from psoriasis symptoms.

In one
study of women with psoriasis, nearly 9 out 10 saw their skin get better or stabilize during pregnancy.

study found that over half of women said their symptoms got better during pregnancy, but 2 out of 3 said their psoriasis got worse after giving birth.

After pregnancy, hormone levels return to normal — so your psoriasis may flare up again.

If you’re taking medication to treat your psoriasis, it’s important to talk with your care team as soon as you start thinking about having a baby. Certain drugs
need to be stopped several months before you become pregnant.


perimenopause, the time when a woman’s body starts making the transition toward menopause, hormonal ups and downs — particularly dropping estrogen levels — may make psoriasis worse.

In a study of menopausal women with psoriasis, nearly half said going through menopause
made their condition worse, and only 2% showed improvement.

Managing hormone-related flares

If your psoriasis is getting worse and you suspect hormones may be to blame, talk to a healthcare provider who understands how hormones affect your condition.

Together, you can discuss treatment options, such as medication that may help ease flares, no matter where you are in your life.

This resource was created with support from Eli Lilly.